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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >SNMP is a signaling component required for pheromone sensitivity in Drosophila
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SNMP is a signaling component required for pheromone sensitivity in Drosophila

机译：SNMP是果蝇中信息素敏感性所需的信号传导成分

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摘要

The only known volatile pheromone in Drosophila, 11-cis-vaccenyl acetate (cVA), mediates a variety of behaviors including aggregation, mate recognition, and sexual behavior. cVA is detected by a small set of olfactory neurons located in T1 trichoid sensilla on the antennae of males and females. Two components known to be required for cVA reception are the odorant receptor Or67d and the extracellular pheromone-binding protein LUSH. Using a genetic screen for cVA-insensitive mutants, we have identified a third component required for cVA reception: sensory neuron membrane protein (SNMP). SNMP is a homolog of CD36, a scavenger receptor important for lipoprotein binding and uptake of cholesterol and lipids in vertebrates. In humans, loss of CD36 is linked to a wide range of disorders including insulin resistance, dyslipidemia, and atherosclerosis, but how CD36 functions in lipid transport and signal transduction is poorly understood. We show that SNMP is required in pheromone-sensitive neurons for cVA sensitivity but is not required for sensitivity to general odorants. Using antiserum to SNMP infused directly into the sensillum lymph, we show that SNMP function is required on the dendrites of cVA-sensitive neurons; this finding is consistent with a direct role in cVA signal transduction. Therefore, pheromone perception in Drosophila should serve as an excellent model to elucidate the role of CD36 members in transmembrane signaling.
机译：果蝇中唯一已知的挥发性信息素11-顺式-乙酸乙烯酯（cVA）介导多种行为，包括聚集，配偶识别和性行为。 cVA由位于雄性和雌性触角上的T1 Trichoid感觉器中的一小组嗅觉神经元检测。已知接受cVA所需的两个成分是气味受体Or67d和细胞外信息素结合蛋白LUSH。使用针对cVA不敏感突变体的遗传筛选，我们确定了cVA接收所需的第三个组件：感觉神经元膜蛋白（SNMP）。 SNMP是CD36的同源物，CD36是一种清道夫受体，对于脊椎动物中脂蛋白的结合以及胆固醇和脂质的摄取很重要。在人类中，CD36的丢失与包括胰岛素抵抗，血脂异常和动脉粥样硬化在内的多种疾病有关，但人们对CD36如何在脂质转运和信号转导中发挥作用却知之甚少。我们表明，对于CVA敏感度，信息素敏感神经元需要SNMP，但对一般气味的敏感度则不需要。使用抗血清直接注入sensillum淋巴液中的SNMP，我们显示SNMP功能对cVA敏感神经元的树突是必需的。这一发现与cVA信号转导中的直接作用是一致的。因此，果蝇中的信息素感知应作为阐明CD36成员在跨膜信号传导中的作用的优良模型。

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