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Some cancer cells evade chemotherapy by expressing cell membrane pumps to expel toxins. One such pump is the P-glycoprotein, which exports the widely used chemotherapy compound Taxol as it passes through the membrane. Torncounter P-glycoprotein efflux, Elena Dubikovskaya et al. modified Taxol's structure, attaching a peptide that alters the mechanism by which the compound enters cells. The new conjugate, with different physical properties, is not a substrate for the pump.

机译：一些癌细胞通过表达细胞膜泵排出毒素来逃避化学疗法。一种这样的泵是P-糖蛋白，当它通过膜时，它会输出广泛使用的化疗化合物紫杉醇。撕裂计数器P糖蛋白流出，Elena Dubikovskaya等。修饰了紫杉醇的结构，附着了一种肽，该肽改变了化合物进入细胞的机制。具有不同物理特性的新结合物不是泵的基质。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第34期|12095-12096|共2页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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