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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Thermostability of model protocell membranes
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Thermostability of model protocell membranes

机译：原型细胞膜的热稳定性

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The earliest cells may have consisted of a self-replicating genetic polymer encapsulated within a self-replicating membrane vesicle. Here, we show that vesicles composed of simple single-chain amphiphiles such as fatty acids, fatty alcohols, and fatty-acid glycerol esters are extremely thermostable and retain internal RNA and DNA oligonucleotides at temperatures ranging from 0℃ to 100℃. The strands of encapsulated double-stranded DNA can be separated by denaturation at high temperature while being retained within vesicles, implying that strand separation in primitive protocells could have been mediated by thermal fluctuations without the loss of genetic material from the protocell. At elevated temperatures, complex charged molecules such as nucleotides cross fatty-acid-based membranes very rapidly, suggesting that high temperature excursions may have facilitated nutrient uptake before the evolution of advanced membrane transporters. The thermostability of these membranes is consistent with the spontaneous replication of encapsulated nucleic acids by the alternation of template-copying chemistry at low temperature with strand-separation and nutrient uptake at high temperature.
机译：最早的细胞可能由包裹在自我复制膜囊中的自我复制遗传聚合物组成。在这里，我们显示由简单的单链两亲物（例如脂肪酸，脂肪醇和脂肪酸甘油酯）组成的囊泡具有极高的耐热性，并且在0℃至100℃的温度范围内保留了内部RNA和DNA寡核苷酸。封装的双链DNA链可以在保留在囊泡中的同时通过高温变性而分离，这意味着原始的原始细胞中的链分离可能是由热波动介导的，而不会损失原始细胞的遗传物质。在升高的温度下，复杂的带电荷分子（如核苷酸）会非常迅速地穿过基于脂肪酸的膜，这表明在高级膜转运蛋白进化之前，高温漂移可能促进了养分的吸收。这些膜的热稳定性与在低温下通过模板复制化学与高温下的链分离和养分吸收的交替发生而与被包裹的核酸的自发复制相一致。

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