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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis
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An integrated mechanobiochemical feedback mechanism describes chromosome motility from prometaphase to anaphase in mitosis

机译：完整的机械生化反馈机制描述了有丝分裂中从前中期到后期的染色体运动

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摘要

During mitosis, chromosomes undergo a series of movements while being end-on attached to the kinetochore microtubules (KMTs) from spindle poles. The mechanism underlying such movements and their physiological functions remains elusive. We describe a mechanobiochemical feedback model of chromosome motility. The key ingredient is a feedback mechanism between the local chemical reactions that control the dynamics of KMTs and the mechanical state of the chromosome via tension-sensitive proteins localized at the kinetochores. This model can recapitulate all of the essential and distinct features of chromosome motilities from prometaphase to anaphase in a coherent manner. We further show that this feedback mechanism provides robust and precise means of guiding the chromosome to the cell equator regardless of the initial conditions and uncertainty in velocity. Predictions of our model can be tested experimentally.
机译：在有丝分裂过程中，染色体经历了一系列运动，同时从纺锤极端端附着在动粒微管（KMT）上。这种运动及其生理功能的潜在机制仍然难以捉摸。我们描述了染色体运动的力学生化反馈模型。关键因素是局部化学反应之间的反馈机制，该化学反应通过定位在动植物体内的张力敏感蛋白来控制KMT的动力学和染色体的机械状态。该模型可以以连贯的方式概括从前中期到后期的染色体能动性的所有基本特征和独特特征。我们进一步表明，这种反馈机制提供了将染色体引导至细胞赤道的鲁棒且精确的方法，而不论初始条件和速度的不确定性如何。我们模型的预测可以通过实验进行测试。

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