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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Infraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons
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Infraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons

机译：神经节细胞光感受器向多巴胺能无长突神经元的视网膜下信号传导

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摘要

Retinal dopaminergic amacrine neurons (DA neurons) play a central role in reconfiguring retinal function according to prevailing illumination conditions, yet the mechanisms by which light regulates their activity are poorly understood. We investigated the means by which sustained light responses are evoked in DA neurons. Sustained light responses were driven by cationic currents and persisted in vitro and in vivo in the presence of L-AP4, a blocker of retinal ON-bipolar cells. Several characteristics of these L-AP4-resistant light responses suggested that they were driven by melanopsin-expressing intrinsically photosensitive retinal ganglion cells (ipRGCs), including long latencies, marked poststimulus persistence, and a peak spectral sensitivity of 478 nm. Furthermore, sustained DA neuron light responses, but not transient DA neuron responses, persisted in rod/cone degenerate retinas, in which ipRGCs account for virtually all remaining retinal phototransduc-tion. Thus, ganglion-cell photoreceptors provide excitatory drive to DA neurons, most likely by way of the coramification of their dendrites and the processes of DA neurons in the inner plexiform layer. This unprecedented centrifugal outflow of ganglion-cell signals within the retina provides a novel basis for the restructuring of retinal circuits by light.
机译：视网膜多巴胺能无长突神经元（DA神经元）根据当前的照明条件在重新配置视网膜功能中起着核心作用，但是光调节其活性的机制却鲜为人知。我们研究了在DA神经元中引起持续光反应的方法。持续的光响应由阳离子电流驱动，并在存在L-AP4（视网膜ON双极细胞的阻滞剂）的情况下在体内和体外持续存在。这些抗L-AP4的光反应的几个特征表明，它们受表达黑素的内在光敏性视网膜神经节细胞（ipRGC）驱动，包括长时延，明显的刺激后持久性和478 nm的峰值光谱敏感性。此外，持续的DA神经元光反应，而不是短暂的DA神经元反应，在视杆/视锥变性视网膜中持续存在，其中ipRGC几乎占据了所有剩余的视网膜光转导。因此，神经节细胞光感受器提供对DA神经元的兴奋性驱动，最有可能是通过其树突的共聚化和内部丛状层中DA神经元的过程。视网膜内神经节细胞信号的这种前所未有的离心流出为光重建视网膜回路提供了新的基础。

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