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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A Potent Dauer Pheromone Component In Caenorhabditis Elegans That Acts Synergistically With Other Components
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A Potent Dauer Pheromone Component In Caenorhabditis Elegans That Acts Synergistically With Other Components

机译：秀丽隐杆线虫中有力的Dauer信息素成分与其他成分协同作用

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摘要

In the model organism Caenorhabditis elegans, the dauer pheromone is the primary cue for entry into the developmentally arrested, dauer larval stage. The dauer is specialized for survival under harsh environmental conditions and is considered "nonag-ing" because larvae that exit dauer have a normal life span. C. elegans constitutively secretes the dauer pheromone into its environment, enabling it to sense its population density. Several components of the dauer pheromone have been identified as derivatives of the dideoxy sugar ascarylose, but additional unidentified components of the dauer pheromone contribute to its activity. Here, we show that an ascaroside with a 3-hydroxypro-pionate side chain is a highly potent component of the dauer pheromone that acts synergistically with previously identified components. Furthermore, we show that the active dauer pheromone components that are produced by C. elegans vary depending on cultivation conditions. Identifying the active components of the dauer pheromone, the conditions under which they are produced, and their mechanisms of action will greatly extend our understanding of how chemosensory cues from the environment can influence such fundamental processes as development, metabolism, and aging in nematodes and in higher organisms.
机译：在模型秀丽隐杆线虫中，dauer信息素是进入发育停滞的dauer幼虫阶段的主要线索。 dauer专门用于在恶劣的环境条件下生存，并且被认为是“不成熟的”，因为退出dauer的幼虫具有正常的寿命。秀丽隐杆线虫组成性地将dauer信息素分泌到其环境中，使其能够感知其种群密度。 dauer信息素的几种成分已被确定为双脱氧糖天冬糖的衍生物，但dauer信息素的其他未确定的成分也对其活性有所贡献。在这里，我们显示具有3-羟基丙酸酯侧链的a螨苷是dauer信息素的高效成分，与先前确定的成分协同作用。此外，我们表明由秀丽隐杆线虫产生的活性道尔费洛蒙成分随培养条件而变化。鉴定道尔费洛蒙的活性成分，其产生的条件以及它们的作用机理将极大地扩展我们对来自环境的化学感觉线索如何影响线虫和线虫的发育，代谢和衰老等基本过程的理解。高等生物。

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