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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cd4 Memory T Cells Divide Poorly In Response To Antigen Because Of Their Cytokine Profile
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Cd4 Memory T Cells Divide Poorly In Response To Antigen Because Of Their Cytokine Profile

机译：Cd4记忆T细胞由于细胞因子的分布而对抗原反应差

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摘要

Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is solely a consequence of the increased antigen-specific precursor frequency within the memory pool. Memory cells proliferated less than primary responding cells, even within the same host. By analyzing the entry of primary and memory cells into the cell cycle, we found that the two populations proliferated similarly until day 5; after this time, fewer of the reactivated memory cells proliferated. At this time, fewer of the reactivated memory cells made IL-2 than primary responding cells, but more made IFNγ. Both these factors affected the low proliferation of the memory cells, because either exogenous IL-2 or inhibition of IFNγ increased the proliferation of the memory cells.
机译：免疫记忆是适应性免疫的标志，而了解T细胞记忆将是开发有效的细胞介导疫苗的关键。 CD4存储单元的特性和功能尚未很好地定义。在这里，我们证明了次级反应大小的增加仅仅是内存池中抗原特异性前体频率增加的结果。即使在同一宿主内，记忆细胞的增殖也少于原代应答细胞。通过分析原代和记忆细胞进入细胞周期的过程，我们发现两个种群的增殖相似，直到第5天。在这段时间之后，较少的重新激活的记忆细胞增殖。此时，与原代应答细胞相比，产生IL-2的重新活化的记忆细胞更少，但是产生IFNγ的细胞更多。这两个因素都影响了记忆细胞的低增殖，因为外源性IL-2或IFNγ的抑制都会增加记忆细胞的增殖。

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