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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Monkeypox Virus Evades Antiviral Cd4~+ And Cd8~+ T Cell Responses By Suppressing Cognate T Cell Activation
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Monkeypox Virus Evades Antiviral Cd4~+ And Cd8~+ T Cell Responses By Suppressing Cognate T Cell Activation

机译：猴痘病毒通过抑制同源T细胞活化来逃避抗Cd4〜+和Cd8〜+ T细胞反应。

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摘要

Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4~+ and CD8~+ T cells could recognize vaccinia virus (VV)-infected monocytes and produce inflammatory cytokines such as IFNγ and TNFα, they were largely incapable of responding to autologous MPV-infected cells. Further analysis revealed that, unlike cowpox virus (CPV), MPV did not interfere with MHC expression or intra-cellular transport of MHC molecules. Instead, MPV-infected cells were capable of preventing T cell receptor (TcR)-mediated T cell activation in trans. The ability to trigger a state of nonresponsive-ness represents a unique MHC-independent mechanism for blocking antiviral T cell activation and inflammatory cytokine production and is likely an important attribute involved with viral dissemination in the infected host.
机译：猴痘病毒（MPV）是一种致命的人类病原体，由于它有可能被用作生物恐怖剂，并且在2003年无意中引入了北美，因此受到了越来越多的关注。美国的爆发也为研究MPV特异性T细胞免疫性提供了重要机会。尽管MPV特异性CD4〜+和CD8〜+ T细胞可以识别感染牛痘病毒（VV）的单核细胞并产生炎性细胞因子，例如IFNγ和TNFα，但它们在很大程度上不能对自体MPV感染的细胞作出反应。进一步的分析表明，与牛痘病毒（CPV）不同，MPV不会干扰MHC表达或MHC分子在细胞内的运输。相反，受MPV感染的细胞能够预防T细胞受体（TcR）介导的T细胞反式激活。触发无反应状态的能力代表了一种独特的MHC独立机制，可阻止抗病毒T细胞活化和炎性细胞因子的产生，并且可能是与病毒在受感染宿主中传播有关的重要属性。

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