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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Blys Inhibition Eliminates Primary B Cells But Leaves Natural And Acquired Humoral Immunity Intact
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Blys Inhibition Eliminates Primary B Cells But Leaves Natural And Acquired Humoral Immunity Intact

机译：Blys抑制消除了原代B细胞，但保留了自然的和获得的体液免疫力

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摘要

We have used an inhibiting antibody to determine whether pre-immune versus antigen-experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation and survival. Whereas in vivo BLyS inhibition profoundly reduced naieve B cell numbers and primary immune responses, it had a markedly smaller effect on memory B cells and long-lived plasma cells, as well as secondary immune responses. There was heterogeneity within the memory pools, because IgM-bearing memory cells were sensitive to BLyS depletion whereas IgG-bearing memory cells were not, although both were more resistant than naive cells. There was also heterogeneity within B1 pools, as splenic but not peritoneal B1 cells were diminished by anti-BLyS treatment, yet the number of natural antibody-secreting cells remained constant. Together, these findings show that memory B cells and natural antibody-secreting cells are BLyS-independent and suggest that these pools can be separately manipulated.
机译：我们已经使用了一种抑制性抗体来确定免疫前的B细胞与抗原经历的B细胞在BLyS（控制分化和存活的细胞因子）的必需条件方面是否有所不同。体内BLyS抑制可大大减少幼稚B细胞的数量和初次免疫反应，但对记忆B细胞和长寿浆细胞以及继发免疫反应的影响明显较小。内存池中存在异质性，因为带有IgM的存储细胞对BLyS耗尽敏感，而带有IgG的存储细胞对BLyS耗尽不敏感，尽管两者都比纯朴的细胞更具抗性。在B1池中也存在异质性，因为通过抗BLyS处理减少了脾脏而非腹膜B1细胞，但天然抗体分泌细胞的数量保持恒定。在一起，这些发现表明记忆B细胞和天然抗体分泌细胞是BLyS无关的，并建议可以单独操作这些池。

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