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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Three-dimensional Brain Growth Abnormalities In Childhood-onset Schizophrenia Visualized By Using Tensor-based Morphometry
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Three-dimensional Brain Growth Abnormalities In Childhood-onset Schizophrenia Visualized By Using Tensor-based Morphometry

机译：通过使用基于张量的形态计量学可视化的儿童发作型精神分裂症的三维脑生长异常

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摘要

Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the developing brain. Here, we use tensor-based morphometry to visualize white matter (WM) growth abnormalities in COS throughout the brain. Using high-dimensional elastic image registration, we compared 3D maps of local WM growth rates in COS patients and healthy children over a 5-year period, based on analyzing longitudinal brain MRIs from 12 COS patients and 12 healthy controls matched for age, gender, and scan interval. COS patients showed up to 2.2% slower growth rates per year than healthy controls in WM (P = 0.02, all P values corrected). The greatest differences were in the right hemisphere (P = 0.006). This asymmetry was attributable to a right slower than left hemisphere growth rate mapped in COS patients (P = 0.037) but not in healthy controls. WM growth rates reached 2.6% per year in healthy controls (P = 0.0002). COS patients showed only a 1.3% per year trend for growth in the left hemisphere (P = 0.066). In COS, WM growth rates were associated with improvement in the Children's Global Assessment Scale (R = 0.64, P = 0.029). Growth rates were reduced throughout the brain in COS, but this process appeared to progress in a front-to-back (frontal-parietal) fashion, and this effect was not attributable to lower IQ. Growth rates were correlated with functional prognosis and were visualized as detailed 3D maps. Finally, these findings also confirm that the progressive GM deficits seen in schizophrenia are not the result of WM overgrowth.
机译：较早的研究表明，儿童期精神分裂症（COS）在发展中的大脑的外侧和内侧表面均会逐渐出现皮质灰质（GM）丢失。在这里，我们使用基于张量的形态来可视化整个大脑中COS中的白质（WM）生长异常。通过分析12位COS患者和12位年龄，性别，健康状况良好的健康对照者的纵向脑部MRI，我们使用高维弹性图像配准，比较了5年内COS患者和健康儿童的局部WM增长率的3D图。和扫描间隔。在WM中，COS患者的年增长率比健康对照组高出2.2％（P = 0.02，所有P值均已校正）。最大的差异在于右半球（P = 0.006）。这种不对称性归因于COS患者的右半球生长速率慢于左半球的生长速率（P = 0.037），但健康对照者并非如此。在健康对照组中，WM增长率达到每年2.6％（P = 0.0002）。 COS患者显示左半球每年仅增长1.3％的趋势（P = 0.066）。在COS中，WM增长率与儿童全球评估量表的改善相关（R = 0.64，P = 0.029）。 COS的整个大脑的生长速度都降低了，但是这个过程似乎以从前到后（额顶）的方式进行，并且这种影响并不归因于智商较低。生长速率与功能预后相关，并显示为详细的3D地图。最后，这些发现还证实了精神分裂症中进行性的GM缺乏不是WM过度生长的结果。

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