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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Kanadi1 Regulates Adaxial-abaxial Polarity In Arabidopsis By Directly Repressing The Transcription Of Asymmetric Leaves2
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Kanadi1 Regulates Adaxial-abaxial Polarity In Arabidopsis By Directly Repressing The Transcription Of Asymmetric Leaves2

机译：Kanadi1通过直接抑制不对称Leaf2的转录调节拟南芥中的正面-背面极性。

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摘要

Lateral organ polarity in Arabidopsis is regulated by antagonistic interactions between genes that promote either adaxial or abaxial identity, but the molecular basis of this interaction is largely unknown. We show that the adaxial regulator ASYMMETRIC LEAVES2 (AS2) is a direct target of the abaxial regulator KANADI1 (KAN1), and that KAN1 represses the transcription of AS2 in abaxial cells. Mutation of a single nucleotide in a KAN1 binding site in the AS2 promoter causes AS2 to be ectopically expressed in abaxial cells, resulting in a dominant, adaxialized phenotype. We also show that the abaxial expression of KAN1 is mediated directly or indirectly by AS2. These results demonstrate that KAN1 acts as a transcriptional repressor and that mutually repressive interactions between KAN1 and AS2 contribute to the establishment of adaxial-abaxial polarity in plants.
机译：拟南芥中的侧向器官极性受促进近轴或近轴同一性的基因之间的拮抗作用所调节，但这种相互作用的分子基础在很大程度上是未知的。我们表明，轴向调节器ASYMMETRIC LEAVES2（AS2）是背面调节器KANADI1（KAN1）的直接目标，并且KAN1抑制了背面细胞中AS2的转录。 AS2启动子中KAN1结合位点中单个核苷酸的突变会导致AS2在背面细胞中异位表达，从而导致显性的轴化表型。我们还显示，KAN1的背面表达是由AS2直接或间接介导的。这些结果表明，KAN1充当转录阻遏物，并且KAN1和AS2之间的相互抑制相互作用有助于植物中左右轴极性的建立。

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