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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Emergence Of Symmetry In Homooligomeric Biological Assemblies
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Emergence Of Symmetry In Homooligomeric Biological Assemblies

机译：同源低聚生物组装中的对称性的出现。

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摘要

Naturally occurring homooligomeric protein complexes exhibit striking internal symmetry. The evolutionary origins of this symmetry have been the subject of considerable speculation; proposals for the advantages associated with symmetry include greater folding efficiency, reduced aggregation, amenability to allosteric regulation, and greater adaptability. An alternative possibility stems from the idea that to contribute to fitness, and hence be subject to evolutionary optimization, a complex must be significantly populated, which implies that the interaction energy between monomers in the ancestors of modern-day complexes must have been sufficient to at least partially overcome the entropic cost of association. Here, we investigate the effects of this bias toward very-low-energy complexes on the distribution of symmetry in primordial homooligomers modeled as randomly interacting pairs of monomers. We demonstrate quantitatively that a bias toward very-low-energy complexes can result in the emergence of symmetry from random ensembles in which the overall frequency of symmetric complexes is vanishingly small. This result is corroborated by using explicit protein-protein docking calculations to generate ensembles of randomly docked complexes: the fraction of these that are symmetric increases from 0.02% in the overall population to ＞ 50% in very low energy subpopulations.
机译：天然存在的低聚蛋白复合物表现出惊人的内部对称性。这种对称性的进化起源一直是人们猜测的主题。与对称性相关的优点的建议包括更高的折叠效率，减少的聚集，对变构调节的适应性以及更大的适应性。另一种可能性源自这样的想法，即有助于适应性并因此要进行进化优化，必须显着填充复合物，这意味着现代复合物祖先中单体之间的相互作用能必须足以达到至少部分克服了协会的熵成本。在这里，我们研究了这种偏向低能络合物的偏向对原始均聚物中对称分布的影响，该均聚物被建模为随机相互作用的单体对。我们定量地证明，偏向非常低能量的配合物可以导致随机集合中对称性的出现，在随机集合中，对称性复合物的总频率逐渐减小。通过使用显式蛋白质-蛋白质对接计算来生成随机对接的复合体的集合，可以证实这一结果：对称的复合体比例从总人口中的0.02％增加到能量非常低的亚群中的> 50％。

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