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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Perk-dependent Regulation Of Lipogenesis During Mouse Mammary Gland Development And Adipocyte Differentiation
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Perk-dependent Regulation Of Lipogenesis During Mouse Mammary Gland Development And Adipocyte Differentiation

机译：小鼠乳腺发育和脂肪细胞分化过程中脂质生成的振作依赖性调节

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摘要

The role of the endoplasmic reticulum stress-regulated kinase, PERK, in mammary gland function was assessed through generation of a targeted deletion in mammary epithelium. Characterization revealed that PERK is required for functional maturation of milk-secreting mammary epithelial cells. PERK-dependent signaling contributes to lipogenic differentiation in mammary epithelium, and perk deletion inhibits the sustained expression of lipogenic enzymes FAS, ACL, and SCD1. As a result, mammary tissue has reduced lipid content and the milk produced has altered lipid composition, resulting in attenuated pup growth. Consistent with PERK-dependent regulation of the lipogenic pathway, loss of PERK inhibits expression of FAS, ACL, and SCD1 in immortalized murine embryonic fibroblasts when cultured under conditions favoring adipocyte differentiation. These findings implicate PERK as a physiologically relevant regulator of the lipogenic pathway.
机译：内质网应激调节激酶PERK在乳腺功能中的作用是通过在乳腺上皮中产生靶向缺失来评估的。特征表明，PERK是分泌乳汁的乳腺上皮细胞功能成熟所必需的。 PERK依赖的信号有助于乳腺上皮中的脂肪形成分化，并且振作缺失抑制脂肪形成酶FAS，ACL和SCD1的持续表达。结果，乳腺组织的脂质含量降低，并且所产生的牛奶改变了脂质组成，导致幼崽生长减弱。与PERK依赖的脂肪生成途径调控相一致，当在有利于脂肪细胞分化的条件下培养时，PERK的丧失会抑制永生化的鼠胚胎成纤维细胞中FAS，ACL和SCD1的表达。这些发现暗示PERK作为生脂途径的生理相关调节剂。

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