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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The Potential Of Desferrioxamine-gallium As An Anti-pseudomonas Therapeutic Agent
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The Potential Of Desferrioxamine-gallium As An Anti-pseudomonas Therapeutic Agent

机译：去铁胺-镓作为抗假单胞菌治疗剂的潜力

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摘要

The opportunistic pathogen Pseudomonas aeruginosa causes infections that are difficult to treat by antibiotic therapy. This bacterium can cause biofilm infections where it shows tolerance to antibiotics. Here we report the novel use of a metallo-complex, desferrioxamine-gallium (DFO-Ga) that targets P. aeruginosa iron metabolism. This complex kills free-living bacteria and blocks biofilm formation. A combination of DFO-Ga and the anti-Pseudomonas antibiotic genta-micin caused massive killing of P. aeruginosa cells in mature biofilms. In a P. aeruginosa rabbit corneal infection, topical administration of DFO-Ga together with gentamicin decreased both infiltrate and final scar size by about 50% compared to topical application of gentamicin alone. The use of DFO-Ga as a Trojan horse delivery system that interferes with iron metabolism shows promise as a treatment for P. aeruginosa infections.
机译：机会病原性铜绿假单胞菌引起的感染难以通过抗生素治疗。该细菌可引起生物膜感染，并表现出对抗生素的耐受性。在这里，我们报告了针对铜绿假单胞菌铁代谢的金属配合物去铁胺-镓（DFO-Ga）的新颖用途。这种复合物杀死了自由生存的细菌并阻止了生物膜的形成。 DFO-Ga和抗假单胞菌抗生素genta-micin的组合可导致成熟生物膜中铜绿假单胞菌细胞的大量杀伤。在铜绿假单胞菌兔角膜感染中，与单独局部施用庆大霉素相比，局部施用DFO-Ga与庆大霉素可将浸润和最终疤痕大小降低约50％。使用DFO-Ga作为干扰铁代谢的特洛伊木马传送系统显示出有望作为铜绿假单胞菌感染的一种治疗方法。

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