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Conformal Geometry Of The Retinal Nerve Fiber Layer

机译:视网膜神经纤维层的保形几何

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摘要

The nerve fiber layer of the human retina is made up of the retinal segments of ganglion cell axons. Its geometry can be described mathematically as a fibration of a 2D domain: a partition of a certain region into smooth curves. Here, we present a simple family of curves that closely models the observed geometry of the nerve fiber layer. For each retina, the pattern depends on 2 parameters, A and B: A computer program determines A and B for a given retina and the theory matches the retina with a standard deviation of ≈6-8°. These particular curves turn out to be the curves that would be generated if the growing ganglion cell axon tip moved down a gradient toward a source of diffusible neuroattractant at the disk and away from a weaker macular diffusible repellant. Thus, this model provides morphological evidence that diffusible substances provide positional information to the embryonic ganglion cell axons in finding their way to the optic nerve head.
机译:人视网膜的神经纤维层由神经节细胞轴突的视网膜节段组成。它的几何形状可以用数学方式描述为2D域的纤维化:将某个区域划分为平滑曲线。在这里,我们提供了一个简单的曲线系列,可以紧密地模拟观察到的神经纤维层的几何形状。对于每个视网膜,模式取决于两个参数,A和B:计算机程序确定给定视网膜的A和B,理论匹配视网膜的标准偏差为≈6-8°。这些特定的曲线结果是,如果正在增长的神经节细胞轴突尖端沿一个梯度朝着圆盘处的可扩散神经吸引剂源并远离较弱的黄斑可扩散驱避剂源向下移动,则将生成这些曲线。因此,该模型提供了形态学证据,表明可扩散物质为胚胎神经节细胞轴突提供了到达视神经头的途径的位置信息。

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