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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Nemy Encodes A Cytochrome B561 That Is Required For Drosophila Learning And Memory
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Nemy Encodes A Cytochrome B561 That Is Required For Drosophila Learning And Memory

机译：Nemy编码果蝇学习和记忆所需的细胞色素B561

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摘要

Although many genes have been shown to play essential roles in learning and memory, the precise molecular and cellular mechanisms underlying these processes remain to be fully elucidated. Here, we present the molecular and behavioral characterization of the Drosophila memory mutant nemy. We provide multiple lines of evidence to show that nemy arises from a mutation in a Drosophila homologue of cytochrome B561. nemy is predominantly expressed in neuroendocrine neurons in the larval brain, and in mushroom bodies and antennal lobes in the adult brain, where it is partially coexpressed with peptidyl α-hydroxylating monooxygenase (PHM), an enzyme required for peptide amidation. Cytochrome b561 was found to be a requisite cofactor for PHM activity and we found that the levels of amidated peptides were reduced in nemy mutants. Moreover, we found that knockdown of PHM gave rise to defects in memory retention. Altogether, the data are consistent with a model whereby cytochrome B561-mediated electron transport plays a role in memory formation by regulating intravesicular PHM activity and the formation of amidated neuropeptides.
机译：尽管已经证明许多基因在学习和记忆中起着至关重要的作用，但这些过程背后的精确分子和细胞机制仍有待充分阐明。在这里，我们介绍果蝇记忆突变nemy的分子和行为表征。我们提供了多条证据来表明，nemy来源于果蝇中细胞色素B561的同源突变。 nemy主要在幼虫大脑的神经内分泌神经元中，以及在成年大脑的蘑菇体和触角中表达，在那里与肽酰胺化的肽基α-羟化单加氧酶（PHM）部分共表达。发现细胞色素b561是PHM活性的必要辅助因子，我们发现在nemy突变体中酰胺化肽水平降低。此外，我们发现敲低PHM会导致内存保留方面的缺陷。总之，这些数据与模型一致，在该模型中，细胞色素B561介导的电子转运通过调节膀胱内PHM活性和酰胺化神经肽的形成在记忆形成中起作用。

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