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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Redundant Mechanisms Mediate Bristle Patterning On The Drosophila Thorax
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Redundant Mechanisms Mediate Bristle Patterning On The Drosophila Thorax

机译：冗余机制介导果蝇胸部的刚毛图案。

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摘要

The thoracic bristle pattern of Drosophila results from the spatially restricted expression of the achaete-scute (ac-sc) genes in clusters of cells, mediated by the activity of many discrete cis-regulatory sequences. However, ubiquitous expression of sc or asense (ase) achieved with a heterologous promoter, in the absence of endogenous ac-sc expression, and the activity of the cis-regulatory elements, allows the development of bristles positioned at wild-type locations. We demonstrate that the products of the genes stripe, hairy, and extramacrochaetae contribute to rescue by antagonizing the activity of Sc and Ase. The three genes are expressed in specific but overlapping spatial domains of expression that form a prepattern that allows precise positioning of bristles. The redundant mechanisms might contribute to the robustness of the pattern. We discuss the possibility that patterning in trans by antagonism is ancestral and that the positional cis-regulatory sequences might be of recent origin.
机译：果蝇的胸部刚毛模式是由于achaete-scute（ac-sc）基因在细胞簇中的空间受限表达所致，这种表达受许多离散的顺式调控序列的介导。但是，在没有内源性ac-sc表达的情况下，用异源启动子实现的sc或asense（酶）的普遍表达以及顺式调节元件的活性都可以使位于野生型位置的刚毛发育。我们证明了条纹，毛和macrochachaaee基因的产物通过拮抗Sc和Ase的活性有助于营救。这三个基因在特定但重叠的表达空间域中表达，这形成了允许精确定位刷毛的预模式。冗余机制可能有助于模式的鲁棒性。我们讨论了通过拮抗作用反式构型是祖传的和顺式位置调节序列可能是最近起源的可能性。

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