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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >NMDA-dependent facilitation of corticostriatal plasticity by the amygdala
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NMDA-dependent facilitation of corticostriatal plasticity by the amygdala

机译：杏仁核依赖NMDA促进皮质上皮可塑性

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Emotions generally improve memory, and the basolateral amygdala (BLA) is believed to mediate this effect. After emotional arousal, BLA neurons increase their firing rate, facilitating memory consolidation in BLA targets. The enhancing effects of BLA activity extend to various types of memories, including motor learning, which is thought to involve activity-dependent plasticity at corticostriatal synapses. However, the underlying mechanisms are unknown. Here we show that the NMDA-to-AMPA (alpha-amino-3hydroxy-5-methyl-4-isoxazolepropionic acid) ratio is nearly twice as high at BLA as compared with cortical synapses onto principal striatal neurons and that activation of BLA inputs greatly facilitates long-term potentiation induction at corticostriatal synapses. This facilitation was NMDA-dependent, but it occurred even when BLA and cortical stimuli were 0.5 s apart during long-term potentiation induction. Overall, these results suggest that BLA activity opens long time windows during which the induction of corticostriatal plasticity is facilitated.
机译：情绪通常会改善记忆力，而基底外侧杏仁核（BLA）被认为可以介导这种作用。情绪唤醒后，BLA神经元会提高其放电频率，从而促进BLA目标的记忆巩固。 BLA活性的增强作用扩展到各种类型的记忆，包括运动学习，这被认为与皮质口突触的活动依赖性可塑性有关。但是，其潜在机制尚不清楚。在这里我们显示，与主要主纹状体神经元的皮质突触相比，BLA的NMDA与AMPA（α-氨基-3羟基-5-甲基-4-甲基-4-异恶唑丙酸）之比几乎高出一倍，并且BLA输入的激活极大促进皮质上皮突触的长期增强诱导。这种促进是NMDA依赖性的，但是即使在长期增强诱导期间BLA和皮质刺激相距0.5 s时也会发生。总体而言，这些结果表明，BLA活性打开了较长的时间窗，在此期间促进了皮质皮质可塑性的诱导。

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