...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction
【24h】

Activity-dependent neurotransmitter-receptor matching at the neuromuscular junction

机译：神经肌肉接头处的活动依赖型神经递质-受体匹配

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Signaling in the nervous system requires matching of neurotransmitter receptors with cognate neurotransmitters at synapses. The vertebrate neuromuscular junction is the best studied cholinergic synapse, but the mechanisms by which acetylcholine is matched with acetylcholine receptors are not fully understood. Because alterations in neuronal calcium spike activity alter transmitter specification in embryonic spinal neurons, we hypothesized that receptor expression in postsynaptic cells follows changes in transmitter expression to achieve this specific match. We find that embryonic vertebrate striated muscle cells normally express receptors for glutamate, GABA, and glycine as well as for acetylcholine. As maturation progresses, acetylcholine receptor expression prevails. Receptor selection is altered when early neuronal calcium-dependent activity is perturbed, and remaining receptor populations parallel changes in transmitter phenotype. In these cases, glutamatergic, GABAergic, and glycinergic synaptic currents are recorded from muscle cells, demonstrating that activity regulates matching of transmitters and their receptors in the assembly of functional synapses.
机译：神经系统中的信号传导需要在突触中使神经递质受体与同源神经递质匹配。脊椎动物的神经肌肉连接是研究最深入的胆碱能突触，但尚不完全了解乙酰胆碱与乙酰胆碱受体匹配的机制。因为神经元钙刺突活性的改变会改变胚胎脊髓神经元中的递质指标，所以我们假设突触后细胞中的受体表达会跟随递质表达的变化而达到这种特定的匹配。我们发现，胚胎脊椎动物的横纹肌细胞通常表达谷氨酸，GABA和甘氨酸以及乙酰胆碱的受体。随着成熟的进行，乙酰胆碱受体表达占主导。当早期神经元钙依赖性活动受到扰动时，受体的选择就会改变，而其余受体群体的递质表型则平行变化。在这些情况下，从肌肉细胞中记录了谷氨酸能，GABA能和甘氨酸能的突触电流，表明活性调节功能性突触的装配中的递质及其受体的匹配。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号