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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
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Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling

机译：Msx2相互作用核靶蛋白（Mint）缺陷揭示了Notch / RBP-J信号传导对胸腺细胞早期分化的负调控

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摘要

Notch/RBP-J signaling is required for generation of early T progenitors (ETP) and promotion of double-negative (DN) 4 cells from DN3 cells in thymocyte differentiation. However, whether Notch affects other steps during thymocyte differentiation remains unknown. Msx2-interacting nuclear target protein (Mint) is an endogenous inhibitor of Notch regulation. Concordantly, by ex vivo analyses of embryonic thymi and in vitro differentiation studies of fetal liver progenitors, we find that Mint deficiency enhances generation of ETP and DN4 cells. Unexpectedly, however. Mint deficiency impairs differentiation of ETP into DN2 cells, suggesting that Notch/RBP-J signaling negatively regulates DN1-DN2 transition.
机译：Notch / RBP-J信号传导是胸腺细胞分化中早期T祖细胞（ETP）的产生和DN3细胞中双阴性（DN）4细胞的促进所必需的。但是，Notch是否在胸腺细胞分化过程中影响其他步骤尚不清楚。与Msx2相互作用的核靶蛋白（Mint）是Notch调节的内源性抑制剂。一致地，通过胚胎胸腺的离体分析和胎儿肝祖细胞的体外分化研究，我们发现薄荷缺乏会增强ETP和DN4细胞的生成。没想到，但是。薄荷缺乏症会损害ETP向DN2细胞的分化，这表明Notch / RBP-J信号负调控DN1-DN2的转化。

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