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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Relational representation in the olfactory system
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Relational representation in the olfactory system

机译：嗅觉系统中的关系表示

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摘要

The perceptual quality of odors usually is robust to variability in concentration. However, maps of neural activation across the olfactory bulb glomerular layer are not stable in this respect; rather, glomerular odor representations both broaden and intensify as odorant concentrations are increased. The relative levels of activation among glomeruli, in contrast, remain relatively stable across concentrations, suggesting that the representation of odor quality may rely on these relational activity patterns. However, the neural normalization mechanisms enabling extraction of such relational representations are unclear. Using glomerular imaging activity profiles from the rat olfactory bulb together with computational modeling, we here show that (ⅰ) global normalization preserves concentration-independent odor-quality information; (ⅱ) perceptual similarities, as assessed behaviorally, are better predicted by normalized than by raw bulbar activity profiles; and (ⅲ) a recurrent excitatory circuit recently described in the olfactory bulb is capable of performing such normalization. We show that global feed-forward normalization in a sensory system is behaviorally relevant, and that a center-surround neural architecture does not necessarily imply center-surround function.
机译：气味的感知质量通常对浓度变化具有鲁棒性。然而，在嗅球肾小球层的神经激活图谱在这方面不稳定。相反，随着气味剂浓度的增加，肾小球气味的表示既扩大又加剧。相反，肾小球之间的相对激活水平在各个浓度下都保持相对稳定，表明气味质量的表示可能依赖于这些关系活动模式。但是，尚不清楚能够提取此类关系表示的神经归一化机制。使用来自大鼠嗅球的肾小球成像活动概况以及计算模型，我们在此处显示（ⅰ）全局归一化可保留浓度无关的气味质量信息； （ⅱ）行为评估中的知觉相似性通过标准化比通过原始延髓活动概况更好地预测； （ⅲ）最近在嗅球中描述的复发性兴奋性电路能够执行这种归一化。我们表明，在感觉系统中的全局前馈归一化在行为上是相关的，并且中心环绕神经结构不一定暗示中心环绕功能。

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