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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A plant porphyria related to defects in plastid import of protochlorophyllide oxidoreductase A
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A plant porphyria related to defects in plastid import of protochlorophyllide oxidoreductase A

机译：与原叶绿素内酯氧化还原酶A的质体输入缺陷有关的植物卟啉

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The plastid envelope of higher plant chloroplasts is a focal point of plant metabolism. It is involved in numerous pathways, including tetrapyrrole biosynthesis and protein translocation. Chloroplasts need to import a large number of proteins from the cytosol because most are encoded in the nucleus. Here we report that a loss-of-function mutation in the outer plastid envelope 16-kDa protein (oep16) gene causes a conditional seedling lethal phenotype related to defects in import and assembly of NADPH:protochloro-phyllide (Pchlide) oxidoreductase A. In the isolated knockout mutant of Arabidopsis thaliana, excess Pchlide accumulated in the dark operated as photosensitizer and provoked cell death during greening. Our results highlight the essential role of the substrate-dependent plastid import pathway of precursor Pchlide oxidoreductase A for seedling survival and the avoidance of devel-opmentally programmed porphyria in higher plants.
机译：高等植物叶绿体的质体包膜是植物新陈代谢的焦点。它涉及许多途径，包括四吡咯生物合成和蛋白质易位。叶绿体需要从细胞质中导入大量蛋白质，因为大多数蛋白质是在细胞核中编码的。在这里，我们报道外质体包膜16-kDa蛋白（oep16）基因中的功能丧失突变导致与NADPH的导入和组装缺陷有关的条件性苗致死表型：原氯叶绿素（Pchlide）氧化还原酶A。拟南芥的分离的敲除突变体，在黑暗中积累的过量Pchlide用作光敏剂，并在绿化过程中引起细胞死亡。我们的结果突出了前体Pchlide氧化还原酶A的底物依赖性质体导入途径对于幼苗存活和避免在高等植物中发育的程序性卟啉症的重要作用。

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