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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Spatial navigation deficit in amnestic mild cognitive impairment
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Spatial navigation deficit in amnestic mild cognitive impairment

机译：遗忘性轻度认知障碍的空间导航功能障碍

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Patients with Alzheimer's disease (AD) frequently have difficulties with spatial orientation in their day-to-day life. Although AD is typically preceded by amnestic mild cognitive impairment (MCI), spatial navigation has not yet been studied in MCI. Sixty-five patients were divided into five groups: probable AD (n = 21); MCI, further classified as amnestic MCI single domain (n = 11); amnestic MCI multiple domain (n = 18), or nonamnestic MCI (n = 7), and subjective memory complaints (n = 8). These patients, together with a group of healthy control subjects (n = 26), were tested by using a four-subtests task that required them to locate an invisible goal inside a circular arena. Each subtest began with an overhead view of the arena showed on a computer monitor. This was followed by a real navigation inside of the actual space, an enclosed arena 2.9 m in diameter. Depending on the subtest, the subjects could use the starting position and/or cues on the wall for navigation. The subtests thus were focused on allocentric and egocentric navigation. The AD group and amnestic MCI multiple-domain group were impaired in all subtests. The amnestic MCI single-domain group was impaired significantly in subtests focused on allocentric orientation and at the beginning of the real space egocentric subtest, suggesting impaired memory for allocentric and real space configurations. Our results suggest that spatial navigation impairment occurs early in the development of AD and can be used for monitoring of the disease progression or for evaluation of presymptomiatic AD.
机译：患有阿尔茨海默氏病（AD）的患者在日常生活中经常会遇到空间取向方面的困难。尽管AD通常在轻度认知障碍（MCI）之前，但尚未在MCI中研究空间导航。 65例患者分为5组：可能的AD（n = 21）； MCI，进一步分类为记忆删除MCI单域（n = 11）；遗忘MCI多域（n = 18）或非遗忘MCI（n = 7）和主观记忆障碍（n = 8）。通过使用四项子测试任务对这些患者以及一组健康对照受试者（n = 26）进行测试，该任务要求他们在圆形竞技场内定位一个看不见的目标。每个子测试都以在计算机监视器上显示的竞技场俯视图开始。接下来是在实际空间内部的真实导航，即直径2.9 m的封闭赛场。根据子测试，受试者可以使用墙上的开始位置和/或提示进行导航。因此，子测试集中于同素心导航和自我中心导航。 AD组和MCI多域记忆删除组在所有子测试中均受损。记忆删除MCI单域组在关注同素中心定向的子测试中以及在真实空间自我中心子测试的开始显着受损，这表明对同心轴和实际空间配置的内存受损。我们的结果表明，空间导航障碍发生在AD的发展早期，可用于监测疾病进展或评估症状前AD。

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