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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >DMY gene induces male development in genetically female (XX) medaka fish
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DMY gene induces male development in genetically female (XX) medaka fish

机译：DMY基因在遗传上的雌性（XX）aka鱼中诱导雄性发育

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摘要

Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.
机译：尽管已经在哺乳动物中鉴定了决定性别的基因SRY / Sry，但尚未在非哺乳动物脊椎动物中鉴定出具有类似功能的同源物和基因。最近，从硬骨鱼fish（Oryzias latipes）Y染色体的性别决定区域克隆了DMY（Y染色体上的DM结构域基因）。已经证明，DMY是男性个体正常发育所必需的。在这项研究中，我们表明携带DMY的117-kb基因组DNA片段能够诱导睾丸分化和随后的XX（遗传上为女性）花aka中的雄性发育。另外，在CMV启动子控制下DMY cDNA的过表达也引起XX性别逆转。这些结果表明，DMY足以使高的雄性发育，并表明高的X和Y染色体之间的功能差异是单个基因。我们的数据表明DMY是脊椎动物中另外一个性别决定基因。

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