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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger
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Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger

机译：脱落酸是人粒细胞中的内源性细胞因子，环状ADP-核糖为第二信使

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摘要

Abscisic acid (ABA) is a phytohormone involved in fundamental physiological processes of higher plants, such as response to abiotic stress (temperature, light, drought), regulation of seed dormancy and germination, and control of stomatal closure. Here, we provide evidence that ABA stimulates several functional activities [phagocytosis, reactive oxygen species and nitric oxide (NO) production, and chemotaxis] of human granulocytes through a signaling pathway sequentially involving a pertussis toxin (PTX)-sensitive G protein/receptor complex, protein kinase A activation, ADP-ribosyl cyclase phosphorylation, and consequent cyclic-ADP-ribose overproduction, leading to an increase of the intracellular Ca~(2+) concentration. The increase of free intracellular ABA and its release by activated human granulocytes indicate that ABA should be considered as a new pro-inflammatory cytokine in humans. This discovery is an intriguing example of conservation of a hormone and its signaling pathway from plants to humans and provides insight into the molecular mechanisms of granulocyte activation, possibly leading to the development of new antiinflammatory drugs.
机译：脱落酸（ABA）是一种植物激素，参与高等植物的基本生理过程，例如对非生物胁迫（温度，光照，干旱）的响应，种子休眠和萌发的调节以及气孔关闭的控制。在这里，我们提供的证据表明，ABA通过依次涉及百日咳毒素（PTX）敏感的G蛋白/受体复合物的信号传导途径刺激人粒细胞的几种功能活性[吞噬作用，活性氧和一氧化氮（NO）产生和趋化性] ，蛋白激酶A激活，ADP-核糖基环化酶磷酸化以及随之而来的环-ADP-核糖过量生产，导致细胞内Ca〜（2+）浓度增加。游离的细胞内ABA的增加及其被活化的人类粒细胞释放的结果表明ABA应该被认为是人类的一种新的促炎细胞因子。这一发现是激素及其从植物到人类的信号传导途径保存的一个引人入胜的例子，并提供了对粒细胞活化的分子机制的认识，这可能导致新的抗炎药的开发。

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