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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >What can a clock mutation in mice tell us about bipolar disorder?
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What can a clock mutation in mice tell us about bipolar disorder?

机译：小鼠的时钟突变能告诉我们有关躁郁症的信息吗？

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摘要

Bipolar disorder, also known as manic-depressive illness, is characterized by episodes of mania and episodes of depression usually interspersed with periods of relatively normal mood. During the manic phase, affected individuals exhibit elevated mood, irritability, increased activity, reduced sleep, hypersexuality, and increased goal-directed activities. Bipolar disorder in its various forms affects > 3% of the population and is associated with a high risk for suicide, substance abuse, and vocational disability. Although several animal models for major depressive disorder have been developed, there are no plausible models for bipolar disorder.
机译：双相情感障碍，也称为躁狂抑郁症，其特征是躁狂发作和抑郁发作通常散布着相对正常的情绪。在躁狂期，受影响的个体表现出情绪升高，烦躁不安，活动增加，睡眠减少，性欲亢进和定向活动增多。各种形式的躁郁症会影响超过3％的人口，并具有自杀，滥用药物和职业残障的高风险。尽管已经开发出了几种用于重度抑郁症的动物模型，但尚无合理的双相情感障碍模型。

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