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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118
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Bacteriocin production as a mechanism for the antiinfective activity of Lactobacillus salivarius UCC118

机译：细菌素生产作为唾液乳杆菌UCC118抗感染活性的机制

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摘要

The mechanisms by which probiotic strains enhance the health of the host remain largely uncharacterized. Here we demonstrate that Lactobacillus salivarius UCC118, a recently sequenced and genetically tractable probiotic strain of human origin, produces a bacte-riocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes. A stable mutant of Lb. salivarius UCC118 that is unable to produce the Abp118 bacteriocin also failed to protect mice against infection with two strains of L. monocytogenes, EGDe and LO28, confirming that bacteriocin production is the primary mediator of protection against this organism. Furthermore, Lb. salivarius UCC118 did not offer any protection when mice were infected with a strain of L. monocytogenes expressing the cognate Abp118 immunity protein AbplM, confirming that the antimicrobial effect is a result of direct antagonism between Lb. salivarius and the pathogen, mediated by the bacteriocin Abp118.
机译：益生菌菌株增强宿主健康的机制在很大程度上尚未阐明。在这里，我们证明了唾液乳杆菌UCC118（一种最近测序且人类可遗传处理的益生菌菌株）在体内产生了一种细菌-riocin，可以显着保护小鼠免受侵入性食源性单核细胞增生李斯特氏菌感染。 Lb的稳定突变体。不能产生Abp118细菌素的唾液UCC118也不能保护小鼠免受两株单核细胞增生李斯特氏菌EGDe和LO28感染，从而证明细菌素的产生是保护这种生物的主要介质。此外，磅。当小鼠感染表达同源Abp118免疫蛋白AbplM的单核细胞增生李斯特氏菌菌株时，唾液UCC118不能提供任何保护作用，这证实了抗菌作用是Lb之间直接拮抗的结果。细菌素Abp118介导的唾液和病原体。

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