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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex
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Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex

机译：围产期暴露于非共面多氯联苯会改变大鼠原发性听觉皮层的tonotopy，感受野和可塑性

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摘要

Noncoplanar polychlorinated biphenyls (PCBs) are widely dispersed in human environment and tissues. Here, an exemplar noncoplanar PCB was fed to rat dams during gestation and throughout three subsequent nursing weeks. Although the hearing sensitivity and brainstem auditory responses of pups were normal, exposure resulted in the abnormal development of the primary auditory cortex (A1). A1 was irregularly shaped and marked by internal nonresponsive zones, its topographic organization was grossly abnormal or reversed in about half of the exposed pups, the balance of neuronal inhibition to excitation for A1 neurons was disturbed, and the critical period plasticity that underlies normal postnatal auditory system development was significantly altered. These findings demonstrate that developmental exposure to this class of environmental contaminant alters cortical development. It is proposed that exposure to noncoplanar PCBs may contribute to common developmental disorders, especially in populations with heritable imbalances in neurotransmitter systems that regulate the ratio of inhibition and excitation in the brain. We conclude that the health implications associated with exposure to noncoplanar PCBs in human populations merit a more careful examination.
机译：非共面多氯联苯（PCB）广泛分布在人类环境和组织中。在这里，示例性非共面多氯联苯在妊娠期间以及随后的三个护理周中被喂给大鼠大坝。尽管幼犬的听力敏感性和脑干听觉反应正常，但暴露会导致初级听觉皮层（A1）异常发育。 A1的形状不规则并带有内部无反应区，在大约一半的暴露幼崽中其地形组织严重异常或反转，A1神经元的神经元抑制与兴奋平衡失调，并且是正常产后听觉的关键时期可塑性系统开发发生了重大变化。这些发现表明，发育暴露于此类环境污染物会改变皮层发育。有人提出，暴露于非共面的多氯联苯可能会导致常见的发育障碍，特别是在神经递质系统中遗传性失衡的人群中，后者调节大脑中抑制和兴奋的比例。我们得出的结论是，与人群接触非共面多氯联苯有关的健康影响值得更仔细的检查。

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