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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity
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Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity

机译：小鼠视交叉上核中的单独振荡细胞群光周期性地与日常活动的开始和结束相耦合

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摘要

The pattern of circadian behavioral rhythms is photoperiod-dependent, highlighted by the conservation of a phase relation between the behavioral rhythm and photoperiod. A model of two separate, but mutually coupled, circadian oscillators has been proposed to explain photoperiodic responses of behavioral rhythm in nocturnal rodents: an evening oscillator, which drives the activity onset and entrains to dusk, and a morning oscillator, which drives the end of activity and entrains to dawn. Continuous measurement of circadian rhythms in clock gene Per1 expression by a bioluminescence reporter enabled us to identify the separate oscillating cell groups in the mouse suprachiasmatic nucleus (SCN), which composed circadian oscillations of different phases and responded to photoperiods differentially. The circadian oscillation in the posterior SCN was phase-locked to the end of activity under three photoperiods examined. On the other hand, the oscillation in the anterior SCN was phase-locked to the onset of activity but showed a bimodal pattern under a long photoperiod [light-dark cycle (LD)18:6]. The bimodality in the anterior SCN reflected two circadian oscillatory cell groups of early and late phases. The anterior oscillation was unimodal under intermediate (LD12:12) and short (LD6:18) photoperiods, which was always phase-lagged behind the posterior oscillation when the late phase in LD18:6 was taken. The phase difference was largest in LD18:6 and smallest in LD6:18. These findings indicate that three oscillating cell groups in the SCN constitute regionally specific circadian oscillations, and at least two of them are involved in photoperiodic response of behavioral rhythm.
机译：昼夜节律性行为节律的模式是光周期依赖性的，突出表现为行为节律和光周期之间的相位关系。已经提出了两个独立但相互耦合的昼夜节律振荡器的模型来解释夜间啮齿动物行为节奏的光周期反应：一个晚上的振荡器驱动活动的发作并带入黄昏，另一个是早晨的振荡器，驱动昼夜活动。活动并夹带到黎明。通过生物发光报告程序连续测量时钟基因Per1表达中的昼夜节律，使我们能够鉴定小鼠视交叉上核（SCN）中单独的振荡细胞群，该细胞群由不同阶段的昼夜节律振荡组成，并对光周期有不同的反应。在检查的三个光周期下，后SCN中的昼夜节律振荡被锁相到活动结束。另一方面，前SCN的振荡被锁相到活动的开始，但是在较长的光周期下显示出双峰模式[明暗循环（LD）18：6]。前SCN的双峰性反映了早期和晚期的两个昼夜节律振荡细胞群。在中等（LD12：12）和短（LD6：18）光周期下，前振荡是单峰的，当采用LD18：6的后期相时，前振荡总是滞后于后振荡。相位差在LD18：6中最大，在LD6：18中最小。这些发现表明，SCN中的三个振荡细胞组构成了区域特定的昼夜节律振荡，其中至少两个与行为节律的光周期反应有关。

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