...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin
【24h】

ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin

机译：胎盘迁徙流中的ApoER2 / VLDL受体和Dab1在独立于Reelin的产后神经元迁移中

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Postnatal migration of interneuron precursors from the subventricular zone to the olfactory bulb occurs in chains that form the substrate for the rostral migratory stream. Reelin is suggested to induce detachment of neuroblasts from the chains when they arrive at the olfactory bulb. Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are involved in chain formation most likely independent of Reelin. F-spondin, which is present in the stream, may act as ligand for ApoER2 and VLDLR. In mice lacking either both receptors or Dab1 chain formation is severely compromised, and as a consequence the rostral migratory stream is virtually absent and neuroblasts accumulate in the subventricular zone. The mutant animals exhibit severe neuroanatomical defects in the subventricular zone and in the olfactory bulb. These data demonstrate a cell-autonomous function of ApoER2, and most likely VLDLR and Dab1, in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin.
机译：中间神经元前体从脑室下区域到嗅球的产后迁移发生在链中，这些链形成了鼻尖迁移流的底物。建议Reelin到达嗅球时诱导成神经细胞从链中脱离。在这里，我们显示ApoER2以及可能的超低密度脂蛋白受体（VLDLR）及其细胞内衔接蛋白Dab1都最有可能独立于Reelin参与链形成。流中存在的F-spondin可以充当ApoER2和VLDLR的配体。在缺乏这两种受体或Dab1链形成的小鼠中，严重受损，因此实际上不存在延髓的迁徙流，并且神经母细胞积聚在脑室下区域。突变动物在脑室下区域和嗅球中显示出严重的神经解剖缺陷。这些数据证明在前脑神经母细胞的产后迁移中，ApoER2以及最可能的VLDLR和Dab1具有细胞自治功能，建议其依赖于Reelin以外的配体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号