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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization
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Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization

机译：gp140免疫诱导的广泛交叉反应的抗HIV-1中和抗体

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摘要

An immunization regimen was evaluated in rabbits consisting of the soluble, oligomeric form of envelope glycoprotein of HIV-1, strain R2 (gp140_(R2)), or the surface component of the same envelope (Env), gp120_(R2), in the adjuvant AS02A. The gp140_(R2) was selected based on its unusual CD4-independent phenotype and the exceptionally broad neutralizing response in the infected donor. The gp140_(R2) immunogen induced antibodies that achieved 50% neutralization of 48/48, and 80% neutralization of 43/46 primary strains of diverse HIV-1 subtypes tested. The strains tested included members of standard panels of subtype B and C strains, and other diverse strains known to be neutralization resistant. The gp120_(R2) induced antibodies that neutralized 9/48 of the same strains. Neutralization was IgG-mediated and HIV-1-specific. These results demonstrate that induction of truly broad spectrum neutralizing antibodies is an achievable goal in HIV-1 vaccine development.
机译：在兔中评估了一种免疫方案，该方案由可溶的寡聚形式的HIV-1包膜糖蛋白，菌株R2（gp140_（R2））或同一包膜（Env）的表面成分gp120_（R2）组成。佐剂AS02A。选择gp140_（R2）是基于其异常的CD4独立表型和受感染供体中异常广泛的中和反应。 gp140_（R2）免疫原诱导的抗体实现了对48/48的50％中和和对测试的各种HIV-1亚型的43/46原代菌株的80％中和。测试的菌株包括B型和C型亚型标准品的成员，以及已知具有中和抗性的其他各种菌株。 gp120_（R2）诱导的抗体中和了相同菌株的9/48。中和是IgG介导的和HIV-1特异性的。这些结果表明，诱导真正的广谱中和抗体是HIV-1疫苗开发中可实现的目标。

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