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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses
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Dopaminergic modulation of short-term synaptic plasticity at striatal inhibitory synapses

机译：多巴胺能调节纹状体抑制性突触的短期突触可塑性

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Circuit properties, such as the selection of motor synergies, have been posited as relevant tasks for the recurrent inhibitory synapses between spiny projection neurons of the neostriatum, a nucleus of the basal ganglia participating in procedural learning and voluntary motor control. Here we show how the dopaminergic system regulates short-term plasticity (STP) in these synapses. STP is thought to endow neuronal circuits with computational powers such as gain control, filtering, and the emergence of transitory net states. But little is known about STP regulation. Employing unitary and population synaptic recordings, we observed that activation of dopamine receptors can modulate STP between spiny neurons. A D_1-class agonist enhances, whereas a D_2-class agonist decreases, short-term depression most probably by synaptic redistribution. Presynaptic receptors appear to be responsible for this modulation. In contrast, STP between fast-spiking interneurons and spiny projection neurons is largely unregulated despite expressing presynaptic receptors. Thus, the present experiments provide an explanation for dopamine actions at the circuit level: the control of STP between lateral connections of output neurons and the reorganization of the balance between different forms of inhibitory transmission. Theoretically, D_1 receptors would promote a sensitive, responsive state for temporal precision (dynamic component), whereas D_2 receptors would sense background activity (static component).
机译：电路特性，例如运动协同的选择，已被确定为新纹状体的棘突状投射神经元，参与程序学习和自愿运动控制的基底神经节核之间的反复抑制性突触的相关任务。在这里，我们显示了多巴胺能系统如何调节这些突触的短期可塑性（STP）。 STP被认为赋予了神经元电路以计算能力，如增益控制，滤波和瞬态网络状态的出现。但是对STP法规知之甚少。利用单位和突触的录音，我们观察到多巴胺受体的激活可以调节棘突神经元之间的STP。 D_1类激动剂增强，而D_2类激动剂减少，短期抑制很可能是通过突触重新分布。突触前受体似乎负责这种调节。相反，尽管表达突触前受体，但快速加标的中间神经元和棘突状投射神经元之间的STP基本上不受调节。因此，本实验为多巴胺在回路水平上的作用提供了一种解释：输出神经元横向连接之间STP的控制以及不同形式的抑制性传递之间平衡的重新组织。从理论上讲，D_1受体会促进对时间精度的敏感，响应状态（动态成分），而D_2受体会感知背景活动（静态成分）。

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