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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evolution of robustness in the signaling network of Pristionchus vulva development
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Evolution of robustness in the signaling network of Pristionchus vulva development

机译：Pristionchus外阴发育信号网络中健壮性的演变

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摘要

Robustness to environmental or genetic perturbation, like any other trait, is affected by evolutionary change. However, direct studies on the interplay of robustness and evolvability are limited and require experimental microevolutionary studies of developmental processes. One system in which such microevolutionary studies can be performed is vulva development in the nematode Pristionchus pacificus. Three vulval precursor cells respond to redundant cell-cell interactions, including signals from the gonad and the epidermal cell P8.p. Interestingly, P. pacificus P8.p is involved in cell fate specification of the future vulva cells by lateral inhibition but is incompetent to respond to the inductive signal from the gonad itself. These functional properties of P8.p are unknown from other nematodes, such as Caenorhabditis elegans. We began an experimental and genetic analysis of the microevo-lution of P8.p function. We show that vulva misspecif ication events differ between Pristionchus strains and species. Similarly, lateral inhibition and developmental competence of P8.p evolved within the genus Pristionchus and between natural isolates of P. pacificus. Surprisingly, in some recombinant inbred lines of two distinct P. pacificus isolates, P8.p gained competence to form vulva tissue, a trait that was never observed in P. pacificus isolates. Our results suggest differences in developmental stability between natural isolates, and we hypothesize that the remarkable evolvability of redundant cell-cell interactions allows for adaptive evolution of robustness to developmental noise.
机译：像其他任何特征一样，对环境或遗传扰动的鲁棒性也受进化变化的影响。然而，关于鲁棒性和可进化性相互作用的直接研究是有限的，并且需要对发展过程进行实验性微进化研究。可以进行这种微进化研究的一种系统是线虫Pristionchus pacificus中的外阴发育。三个外阴前体细胞对多余的细胞间相互作用作出反应，包括来自性腺和表皮细胞P8.p的信号。有趣的是，P。pacificus P8.p通过侧向抑制作用参与了未来外阴细胞的细胞命运规范，但对来自性腺本身的诱导信号无能为力。其他线虫（如秀丽隐杆线虫）尚不了解P8.p的这些功能特性。我们开始了对P8.p功能微进化的实验和遗传分析。我们表明，Pristionchus菌株和物种之间的外阴错误指定事件有所不同。同样，P8.p的侧向抑制和发育能力在Pristionchus属中以及在P. pacificus的天然分离物之间演化。出人意料的是，在一些由两个截然不同的P. pacificus分离株组成的重组近交系中，P8.p获得了形成外阴组织的能力，这在P. pacificus分离株中从未观察到。我们的结果表明天然分离物之间发育稳定性的差异，并且我们假设冗余的细胞间相互作用的显着可进化性允许对发育噪声的鲁棒性进行适应性进化。

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