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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies
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U bodies are cytoplasmic structures that contain uridine-rich small nuclear ribonucleoproteins and associate with P bodies

机译：U体是含有富含尿苷的小核糖核糖核蛋白并与P体缔合的胞质结构

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摘要

Uridine-rich small nuclear ribonucleoproteins (U snRNPs) are involved in key steps of pre-mRNA processing in the nucleus of eukaryotic cells. U snRNPs are enriched in the nucleus in discrete organelles that include speckles, Cajal bodies, and histone locus bodies. However, most U snRNPs are assembled in the cytoplasm, not in the nucleus. Despite extensive biochemical information, little is known about the spatial organization of U snRNPs in the cytoplasm. Here we show that U snRNPs in Drosophila are concentrated in discrete cytoplasmic structures, which we call U bodies, because they contain the major U snRNPs. In addition to snRNPs, U bodies contain essential snRNP assembly factors, suggesting that U bodies are sites for assembly or storage of snRNPs before their import into the nucleus. U bodies invariably associate with P bodies, which are involved in RNA surveillance and decay. Genetic disruption of P body components affects the organization of U bodies, suggesting that the two cytoplasmic bodies may cooperate in regulating aspects of snRNP metabolism. The identification of U bodies provides an opportunity to correlate specific biochemical steps of snRNP biogenesis with structural features of the cytoplasm.
机译：富含尿苷的小核糖核蛋白（U snRNPs）参与真核细胞核中的mRNA前加工的关键步骤。 U snRNPs在包括斑点，Cajal体和组蛋白基因座体在内的离散细胞器的细胞核中富集。但是，大多数U snRNPs组装在细胞质中，而不是细胞核中。尽管有广泛的生化信息，对细胞质中U snRNPs的空间组织知之甚少。在这里，我们显示果蝇中的U snRNPs集中在离散的胞质结构中，我们称其为U体，因为它们包含主要的U snRNPs。除snRNPs外，U体还包含重要的snRNP组装因子，这表明U体是将snRNPs导入核之前进行组装或存储的位点。 U体始终与P体相关，而P体参与RNA监测和衰变。 P体成分的遗传破坏会影响U体的组织，这表明两个胞质体可能在调节snRNP代谢方面相互配合。 U体的鉴定提供了将snRNP生物发生的特定生化步骤与细胞质结构特征相关联的机会。

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