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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cardiac beat-to-beat alternations driven by unusual spiral waves
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Cardiac beat-to-beat alternations driven by unusual spiral waves

机译：不寻常的螺旋波驱动的心脏搏动交替

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摘要

Alternans, a beat-to-beat temporal alternation in the sequence of heartbeats, is a known precursor of the development of cardiac fibrillation, leading to sudden cardiac death. The equally important precursor of cardiac arrhythmias is the rotating spiral wave of electro-mechanical activity, or reentry, on the heart tissue. Here, we show that these two seemingly different phenomena can have a remarkable relationship. In well controlled in vitro tissue cultures, isotropic populations of rat ventricular myocytes sustaining a temporal rhythm of alternans can support period-2 oscillatory reentries and vice versa. These reentries bear "line defects" across which the phase of local excitation slips rather abruptly by 2π, when a full period-2 cycle of alternans completes in 4π. In other words, the cells belonging to the line defects are period-1 oscillatory, whereas all of the others in the bulk medium are period-2 oscillatory. We also find that a slowly rotating line defect results in a quasi-periodic like oscillation in the bulk medium. Some key features of these phenomena can be well reproduced in computer simulations of a nonlinear reaction-diffusion model.
机译：Alternans是心跳序列中逐次跳动的时间交替，是导致心脏纤颤并导致心脏猝死的已知先兆。心律不齐的同等重要的先兆是在心脏组织上的机电活动或折返的旋转螺旋波。在这里，我们证明了这两个看似不同的现象可能具有显着的关系。在控制良好的体外组织培养中，维持交替RNA时间节律的大鼠心室肌细胞各向同性群体可以支持2期振荡再进入，反之亦然。这些折返带有“线缺陷”，当交替素的整个周期2周期以4π完成时，局部激励的相位在该线缺陷上突然突变2π。换句话说，属于线路缺陷的单元是周期1振荡的，而大容量介质中的所有其他单元都是周期2振荡的。我们还发现，缓慢旋转的线缺陷会导致散装介质中出现类似准周期的振荡。这些现象的一些关键特征可以在非线性反应扩散模型的计算机仿真中很好地再现。

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