...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Telomere length is paternally inherited and is associated with parental lifespan
【24h】

Telomere length is paternally inherited and is associated with parental lifespan

机译：端粒长度是父系遗传，与父母的寿命有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Telomere length (TL) is emerging as a biomarker for aging and survival. To evaluate factors influencing this trait, we measured TL in a large homogeneous population, estimated the heritability (h~2), and tested for parental effects on TL variation. Our sample included 356 men and 551 women, aged 18-92 years, from large Amish families. Mean TL in leukocytes was measured by quantitative PCR (mean: 6,198 ± 1,696 bp). The h~2 of TL was 0.44 ± 0.06 (P < 0.001), after adjusting for age, sex, and TL assay batch. As expected, TL was negatively correlated with age (r = -0.40; P < 0.001). There was no significant difference in TL between men and women, consistent with our previous findings that Amish men lived as long as Amish women. There was a stronger and positive correlation and association between TL in the offspring and paternal TL (r = 0.46, P < 0.001; β = 0.22, P = 0.006) than offspring and maternal TL (r = 0.18, P = 0.04; β = -0.02, P = 0.4). Furthermore, we observed a positive correlation and association between daughter's TL and paternal lifespan (r = 0.20, P < 0.001; β = 0.21, P = 0.04), but not between daughter's TL and maternal lifespan (r = -0.01, β = 0.04; both P = not significant). Our data, which are based on one of the largest family studies of human TL, support a link between TL and aging and lifespan and suggest a strong genetic influence, possibly via an imprinting mechanism, on TL regulation.
机译：端粒长度（TL）逐渐成为衰老和生存的生物标记。为了评估影响此性状的因素，我们在大量同质种群中测量了TL，估算了遗传力（h〜2），并测试了父母对TL变异的影响。我们的样本包括来自大型阿米什人家庭的356名男性和551名女性，年龄在18-92岁之间。通过定量PCR测量白细胞中的平均TL（平均值：6,198±1,696 bp）。在调整了年龄，性别和TL检测批次之后，TL的h〜2为0.44±0.06（P <0.001）。正如预期的那样，TL与年龄呈负相关（r = -0.40； P <0.001）。男女之间的TL没有显着差异，这与我们先前的发现一致，即阿米什人的寿命与阿米什人的寿命相同。与后代和母体TL（r = 0.18，P = 0.04;β=）相比，后代和母体TL之间的TL之间有更强的正相关和关联（r = 0.46，P <0.001;β= 0.22，P = 0.006）。 -0.02，P = 0.4）。此外，我们观察到女儿的TL和父亲的寿命之间存在正相关和相关性（r = 0.20，P <0.001；β= 0.21，P = 0.04），而不是女儿的TL与母亲的寿命之间（r = -0.01，β= 0.04） ；两个P =不重要）。我们的数据基于人类TL的最大的家族研究之一，支持TL与衰老和寿命之间的联系，并暗示可能通过印迹机制对TL调控产生强大的遗传影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号