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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection
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CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection

机译：依赖CCR6募集吞噬细胞对于快速CD4 T细胞对局部细菌感染的反应非常必要

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摘要

The contribution of CCR6 and phagocyte recruitment to the initiation of T cell responses to a local pathogen is unclear. CD4 T cell activation to an injected soluble antigen occurred rapidly and was completely CCR6-independent. In marked contrast, the tempo of pathogen-specific CD4 T cell activation depended on whether the antigen was secreted or cell-associated. Furthermore, lymph node pathogen-specific CD4 T cell activation required CCR6 and cell migration from the site of infection. Surprisingly, adoptive transfer of wild-type blood phagocytes rescued bacteria-specific T cell activation in CCR6-deficient rnmice, even when these cells were unable to participate in direct antigen presentation. These data demonstrate that T cell responses to a local bacterial infection follow a distinct tempo, largely determined by bacterial protein secretion, and that CCR6-mediated blood phagocyte recruitment to the site of infection is a critical step in the initiation of pathogen-specific immune responses in skin draining lymph nodes.
机译：CCR6和吞噬细胞募集对启动T细胞对局部病原体反应的贡献尚不清楚。 CD4 T细胞对注入的可溶性抗原的激活迅速发生，并且完全不依赖CCR6。与之形成鲜明对比的是，病原体特异性CD4 T细胞活化的速度取决于抗原是分泌还是细胞相关。此外，淋巴结病原体特异性CD4 T细胞活化需要CCR6和细胞从感染部位迁移。出乎意料的是，野生型吞噬细胞的过继转移拯救了CCR6缺陷型小鼠中细菌特异性T细胞的活化，即使这些细胞无法参与直接的抗原呈递。这些数据表明，T细胞对局部细菌感染的反应遵循截然不同的速度，很大程度上取决于细菌蛋白的分泌，而CCR6介导的吞噬细胞募集到感染部位是启动病原体特异性免疫反应的关键步骤在皮肤引流淋巴结中。

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