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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Neural stem cells for Parkinson's disease: To protect and repair
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Neural stem cells for Parkinson's disease: To protect and repair

机译：神经干细胞治疗帕金森氏症：保护和修复

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摘要

Stem cells" and "Parkinson's disease" are four words that signify some of the most important translational research in neuro-science. The imagination of scientists has been captured by the notion that there exists a single "stem" cell, a mother or queen of all cells, with the ability to self-renew and to generate all other cells in an organism. In other words, stem cells are capable of generating various committed progenitor cells and ultimately differentiating into mature cells. Although many investigators have found numerous multipotent and pluripotent cell lines from a variety of sources, it is absolutely critical that we begin to develop the clinical technology to actually use those cells in disease. For Parkinson's disease, it will take significant experimental studies in primate models to demonstrate safety and efficacy prior to human clinical trials.
机译：“干细胞”和“帕金森氏病”是四个词，表示神经科学中一些最重要的转化研究。科学家的想象力被一个单一的“干”细胞（母亲的母亲或女王）所吸引。所有细胞都具有自我更新的能力，并能在生物体中生成所有其他细胞，换句话说，干细胞能够生成各种定型祖细胞并最终分化为成熟细胞，尽管许多研究人员发现了许多专能和多能性来自多种来源的细胞系，对于开始实际使用这些细胞的疾病的临床技术的开发至关重要，对于帕金森氏病，需要在灵长类动物模型中进行大量的实验研究，以证明在人类临床之前的安全性和有效性审判。

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