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Sodium channels amplify spine potentials

机译：钠通道可增强脊柱电位

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摘要

Dendritic spines mediate most excitatory synapses in the brain. Past theoretical work and recent experimental evidence have suggested that spines could contain sodium channels. We tested this by measuring the effect of the sodium channel blocker tetro-dotoxin (TTX) on depolarizations generated by two-photon uncaging of glutamate on spines from mouse neocortical pyramidal neurons. In practically all spines examined, uncaging potentials were significantly reduced by TTX. This effect was postsynaptic and spatially localized to the spine and occurred with uncaging potentials of different amplitudes and in spines of different neck lengths. Our data confirm that spines from neocortical pyramidal neurons are electrically isolated from the dendrite and indicate that they have sodium channels and are therefore excitable structures. Spine sodium channels could boost synaptic potentials and facilitate action potential backpropagation.
机译：树突棘介导大脑中大多数兴奋性突触。过去的理论工作和最近的实验证据表明，刺可能含有钠通道。我们通过测量钠通道阻滞剂河豚毒素（TTX）对来自小鼠新皮层锥体神经元的棘突上光子的双光子解谷氨酸产生的去极化作用的影响，进行了测试。在几乎所有检查过的棘中，TTX均显着降低了解笼潜力。这种作用是突触后的，并且在空间上局限在脊柱，并以不同幅度和不同颈长的棘突出现。我们的数据证实，新皮层锥体神经元的棘与树突电气隔离，表明它们具有钠通道，因此是可兴奋的结构。脊柱钠通道可增强突触电位并促进动作电位的反向传播。

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