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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator
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Human endometriosis is associated with plasma cells and overexpression of B lymphocyte stimulator

机译：人子宫内膜异位症与浆细胞和B淋巴细胞刺激物的过表达有关

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摘要

Endometriosis affects 10-20% of women of reproductive age and is associated with pelvic pain and infertility, and its pathogenesis is not well understood. We used genomewide transcriptional profiling to characterize endometriosis and found that it exhibits a gene expression signature consistent with an underlying autoimmune mechanism. Endometriosis lesions are characterized by the presence of abundant plasma cells, many of which produce IgM, and macrophages that produce BLyS/BAFF/TNFSF13B, a member of the TNF superfamily implicated in other autoimmune diseases. B lymphocyte stimulator (BLyS) protein was found elevated in the serum of endometriosis patients. These observations suggest a model for the pathology of endometriosis where BLyS-responsive plasma cells interact with retrograde menstrual tissues to give rise to endometriosis lesions.
机译：子宫内膜异位症会影响10-20％的育龄妇女，并伴有盆腔疼痛和不孕症，其发病机理尚不清楚。我们使用全基因组转录谱来表征子宫内膜异位症，发现它表现出与潜在的自身免疫机制一致的基因表达特征。子宫内膜异位病变的特征是存在大量浆细胞，其中许多产生IgM，巨噬细胞产生BLyS / BAFF / TNFSF13B，这是与其他自身免疫性疾病有关的TNF超家族成员。发现子宫内膜异位症患者血清中的B淋巴细胞刺激因子（BLyS）蛋白升高。这些观察结果提示了子宫内膜异位症的病理模型，其中BLyS反应性浆细胞与月经逆行组织相互作用，引起子宫内膜异位症。

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