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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Coevolution of robustness, epistasis, and recombination favors asexual reproduction
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Coevolution of robustness, epistasis, and recombination favors asexual reproduction

机译：健壮性，上位性和重组的共同进化促进无性繁殖

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摘要

The prevalence of sexual reproduction remains one of the most perplexing phenomena in evolutionary biology. The deterministic mutation hypothesis postulates that sexual reproduction will be advantageous under synergistic epistasis, a condition in which mutations cause a greater reduction in fitness when combined than would be expected from their individual effects. The inverse condition, antagonistic epistasis, correspondingly is predicted to favor asexual reproduction. To assess this hypothesis, we introduce a finite population evolutionary process that combines a recombination modifier formalism with a gene-regulatory network model. We demonstrate that when reproductive mode and epistasis are allowed to coevolve, asexual reproduction outcom-petes sexual reproduction. In addition, no correlation is found between the level of synergistic epistasis and the fixation time of the asexual mode. However, a significant correlation is found between the level of antagonistic epistasis and asexual mode fixation time. This asymmetry can be explained by the greater reduction in fitness imposed by sexual reproduction as compared with asexual reproduction. Our findings present evidence and suggest plausible explanations that challenge both the deterministic mutation hypothesis and recent arguments asserting the importance of emergent synergistic epistasis in the maintenance of sexual reproduction.
机译：有性生殖的流行仍然是进化生物学中最困惑的现象之一。确定性突变假说假设，在协同上位情况下，有性生殖将是有利的，在这种情况下，突变组合在一起时会导致其适应性降低的幅度大于其个体影响。相应地，相反的情况，拮抗上皮被认为有利于无性繁殖。为了评估该假设，我们引入了一个有限的种群进化过程，该过程将重组修饰符形式主义与基因调控网络模型结合在一起。我们证明，当生殖方式和上位性共同发展时，无性繁殖胜过有性繁殖。此外，在协同上位水平和无性模式的固定时间之间未发现相关性。然而，在拮抗上皮的水平和无性模式固定时间之间发现了显着的相关性。这种不对称性可以通过有性生殖与无性生殖相比更大程度地降低适应性来解释。我们的发现提供了证据，并提出了对确定性突变假说和最近的论点都提出质疑的合理解释，这些论断断言了出现的协同上位性在维持性生殖中的重要性。

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