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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance
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Gamma oscillations dynamically couple hippocampal CA3 and CA1 regions during memory task performance

机译：在记忆任务执行期间，伽马振荡会动态耦合海马CA3和CA1区

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摘要

The hippocampal formation is believed to be critical for the encoding, consolidation, and retrieval of episodic memories. Yet, how these processes are supported by the anatomically diverse hippocampal networks is still unknown. To examine this issue, we tested rats in a hippocampus-dependent delayed spatial alternation task on a modified T maze while simultaneously recording local field potentials from dendritic and somatic layers of the dentate gyrus, CA3, and CA1 regions by using high-density, 96-site silicon probes. Both the power and coherence of gamma oscillations exhibited layer-specific changes during task performance. Peak increases in the gamma power and coherence were found in the CA3-CA1 interface on the maze segment approaching the T junction, independent of motor aspects of task performance. These results show that hippocampal networks can be dynamically coupled by gamma oscillations according to specific behavioral demands. Based on these findings, we propose that gamma oscillations may serve as a physiological mechanism by which CA3 output can coordinate CA1 activity to support retrieval of hippocampus-dependent memories.
机译：海马的形成被认为对于情景记忆的编码，巩固和恢复至关重要。然而，如何在解剖学上多样化的海马网络支持这些过程仍是未知的。为了研究这个问题，我们在改良的T迷宫上测试了海马依赖性延迟空间交替任务中的大鼠，同时通过使用高密度[96]来记录齿状回，CA3和CA1区的树突和体细胞层的局部场电势。现场硅探针。伽玛振荡的功率和相干性在任务执行过程中均表现出特定于层的变化。在接近T型结的迷宫路段的CA3-CA1接口中，发现了伽马功率和相干性的峰值增加，而与任务执行的运动方面无关。这些结果表明，海马网络可以根据特定的行为需求通过伽马振动来动态耦合。基于这些发现，我们建议伽玛振荡可以作为一种生理机制，CA3输出可以通过该生理机制协调CA1的活动以支持对海马依赖性记忆的检索。

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