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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Has hair cell loss MET its match?
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Has hair cell loss MET its match?

机译：MET的脱毛细胞匹配吗？

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摘要

Humans, like all animals, depend on sensory systems to perceive different aspects of the physical world. One of the most remarkable achievements of evolution has been the development of sensory cells that are specialized to detect unique aspects of this world such as a single photon or a single molecular odorant. Similarly, our ability to perceive sound is mediated through the vibration of exquisitely sensitive stereo-ciliary bundles located on the luminal surfaces of mechanosensory hair cells. A deflection of a little as 1 nM at the tip of the stereociliary bundle is sufficient to elicit a change in the resting potential and synaptic activity of the cell (1). Unraveling the molecular mechanisms that mediate the perception of physical stimuli has been one of the most exciting and rewarding endeavors in modern biology.
机译：像所有动物一样，人类也依赖于感觉系统来感知物理世界的不同方面。进化最显着的成就之一就是感觉细胞的发展，该细胞专门用于检测这个世界的独特方面，例如单个光子或单个分子气味剂。同样，我们感知声音的能力是通过位于机械感觉毛细胞腔表面上的非常敏感的立体纤毛束的振动来介导的。立体睫状束末端的挠曲小至1 nM足以引起细胞静息电位和突触活性的改变（1）。阐明介导物理刺激感知的分子机制一直是现代生物学中最令人兴奋和最有意义的努力之一。

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