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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Arousal of cerebral cortex electroencephalogram consequent to high-frequency stimulation of ventral medullary reticular formation
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Arousal of cerebral cortex electroencephalogram consequent to high-frequency stimulation of ventral medullary reticular formation

机译：高频刺激腹侧延髓网状结构引起的大脑皮质脑电图的唤醒

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We have theorized that large neurons in the ventral and medial reticular formation of the medulla are critical for both autonomic and cortical arousal. To test this theory, we anesthetized rats with urethane, lowered concentric bipolar stimulating electrodes into the medullary reticular formation, and implanted electroencephalogram (EEG) and ECG recording electrodes. We stimulated in the medulla with pulse frequencies ranging from 50 to 300 Hz while recording cortical EEG and ECG. These female rats were ovariectomized , and one subgroup was administered estradiol. Electrical stimulation at either 200 or 300 Hz among the large medullary reticular neurons in nucleus paragigantocellularis (PGi) caused a significant reduction in the portion of the EEG power spectrum represented by 6-waves (0.1-4 Hz) and θ-waves (4.1-8 Hz). Correspondingly, there were increases in y-wave power (22-50 Hz), especially when using 300 Hz. Stimulation at ≤ 100 Hz produced fewer changes in cortical EEG. The major features of these results were not significantly different according to estradiol treatment. In contrast, estradiol administration significantly lowered ECG. Electrical stimulation in PGi increased ECG in vehicle control animals, but decreased it in estradiol-treated animals. Regarding the EEG, we conclude that, even in anesthetized animals, stimulation of PGi reticular neurons can increase cortical arousal and that high frequencies of stimulation amplify this effect.
机译：我们的理论认为，延髓腹侧和网状内侧的大神经元对于自主神经和皮层唤醒都是至关重要的。为了验证该理论，我们用氨基甲酸乙酯麻醉了大鼠，将同心双极刺激电极降低到了网状网状组织中，并植入了脑电图（EEG）和ECG记录电极。我们在髓质中以50至300 Hz的脉冲频率进行刺激，同时记录皮层脑电图和心电图。将这些雌性大鼠切除卵巢，并给一个亚组施用雌二醇。副巨神经细胞核（PGi）的大型髓状网状神经元中200或300 Hz的电刺激导致6波（0.1-4 Hz）和θ波（4.1- 8 Hz）。相应地，y波功率（22-50 Hz）有所增加，尤其是在使用300 Hz时。在≤100 Hz的刺激下，皮层脑电图的变化较小。根据雌二醇治疗，这些结果的主要特征无明显差异。相反，雌二醇给药显着降低了ECG。 PGi中的电刺激在媒介物对照动物中增加了ECG，但在雌二醇治疗的动物中降低了ECG。关于脑电图，我们得出结论，即使在麻醉的动物中，PGi网状神经元的刺激也会增加皮层的觉醒，而高频率的刺激会放大这种作用。

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