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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Charge transport and intrinsic fluorescence in amyloid-like fibrils
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Charge transport and intrinsic fluorescence in amyloid-like fibrils

机译：淀粉样蛋白原纤维中的电荷传输和固有荧光

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摘要

The self-assembly of polypeptides into stable, conductive, and intrinsically fluorescent biomolecular nanowires is reported. We have studied the morphology and electrical conduction of fibrils made of an elastin-related polypeptide, poly(ValGlyGlyLeuGly). These amyloid-like nanofibrils, with a diameter ranging from 20 to 250 nm, result from self-assembly in aqueous solution at neutral pH. Their morphological properties and conductivity have been investigated by atomic force microscopy, scanning tunneling microscopy, and two-terminal transport experiments at the micro-and nanoscales. We demonstrate that the nanofibrils can sustain significant electrical conduction in the solid state at ambient conditions and have remarkable stability. We also show intrinsic blue-green fluorescence of the nanofibrils by confocal microscopy analyses. These results indicate that direct (label-free) excitation can be used to investigate the aggregation state or the polymorphism of amyloid-like fibrils (and possibly of other proteinaceous material) and open up interesting perspectives for the use of peptide-based nanowire structures, with tunable physical and chemical properties, for a wide range of nanobiotechnological and bioelectronic applications.
机译：据报道，多肽自组装成稳定的，导电的和固有荧光的生物分子纳米线。我们已经研究了由弹性蛋白相关多肽poly（ValGlyGlyLeuGly）制成的原纤维的形态和导电性。这些淀粉样纳米纤维的直径在20到250 nm之间，是由于在中性pH下在水溶液中自组装而产生的。已经通过原子力显微镜，扫描隧道显微镜以及在微米和纳米级的两末端传输实验研究了它们的形态学性质和电导率。我们证明了纳米原纤维可以在环境条件下在固态下维持显着的导电性，并具有显着的稳定性。我们还通过共聚焦显微镜分析显示了纳米原纤维的固有蓝绿色荧光。这些结果表明，直接（无标记）激发可用于研究淀粉样蛋白原纤维（可能还有其他蛋白质材料）的聚集状态或多态性，并为基于肽的纳米线结构的使用开辟了有趣的前景，具有可调的物理和化学特性，适用于广泛的纳米生物技术和生物电子应用。

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