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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Synergic mechanism and fabrication target for bipedal nanomotors
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Synergic mechanism and fabrication target for bipedal nanomotors

机译：双足纳米电机的协同机理及制备目标

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Inspired by the discovery of dimeric motor proteins capable of undergoing transportation in living cells, significant efforts have been expended recently to the fabrication of track-walking nanomotors possessing two foot-like components that each can bind or detach from an array of anchorage groups on the track in response to local events of reagent consumption. The central problem in fabricating bipedal nanomotors is how the motor as a whole can gain the synergic capacity of directional track-walking, given the fact that each pedal component alone often is incapable of any directional drift. Implemented bipedal motors to date solve this thermodynamically intricate problem by an intuitive strategy that requires a hetero-pedal motor, multiple anchorage species for the track, and multiple reagent species for motor operation. Here we performed realistic molecular mechanics calculations on molecule-scale models to identify a detailed molecular mechanism by which motor-level directionality arises from a homo-pedal motor along a minimally heterogeneous track. Optimally, the operation may be reduced to a random supply of a single species of reagents to allow the motor's autonomous functioning. The mechanism suggests a distinct class of fabrication targets of drastically reduced system requirements. Intriguingly, a defective form of the mechanism falls into the realm of the well known Brownian motor mechanism, yet distinct features emerge from the normal working of the mechanism.
机译：受发现能够在活细胞中运输的二聚体运动蛋白启发，近来，人们付出了巨大的努力来制造具有两个脚状组件的履带行走纳米电机，每个组件可以结合或脱离固定在基团上的一系列锚定基团。跟踪试剂消耗的本地事件。考虑到每个踏板组件通常通常无法产生任何方向性漂移的事实，制造双足纳米电机的中心问题是整个电机如何获得定向履带的协同能力。迄今为止，已实现的双足电动机通过一种直观的策略解决了这个热力学复杂的问题，该策略需要一个异脚踏电动机，用于履带的多种锚固物质以及用于电动机运行的多种试剂物质。在这里，我们在分子尺度模型上进行了现实的分子力学计算，以识别详细的分子机制，通过该机制，同级电机沿着最小的异质轨迹产生了电机级的方向性。理想情况下，可以将操作减少为随机提供一种试剂，以使电动机具有自主功能。该机制提出了大幅降低系统要求的独特制造目标。有趣的是，该机构的一种缺陷形式落入了众所周知的布朗电机机构的领域，但是从该机构的正常工作中却出现了明显的特征。

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