Genes found for deadly mushroom toxins

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Genes found for deadly mushroom toxins

机译：发现致命蘑菇毒素的基因

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In fungi, until now, all known cyclic peptides were thought to be produced by nonribosomal peptide synthases (NRPSs), with each enzyme dedicated to making only one peptide. Heather Hallen et al. shotgun-sequenced the genome of Amanita bisporigera (the "destroying angel") and found that α-amanitin and phallotoxin, cyclic toxins responsible for fatal mushroom poisoning by Amanita mushrooms, are expressed from genes in the mushrooms' genomes. After a search turned up no matches to the DNA coding for known NRPSs, the authors searched for cyclic permutations of the amino acids coding for amanitins and phallotoxins. Indeed, the mushroom genome contained an amanitin gene, AMA1, and two copies of a phallacidin gene, PHA1.

机译：在真菌中，直到现在，所有已知的环肽都被认为是由非核糖体肽合酶（NRPS）产生的，每种酶仅致力于制造一种肽。希瑟·哈伦（Heather Hallen）等。弹枪对双孢鹅膏菌（“毁灭性天使”）的基因组进行了测序，结果发现，由蘑菇的基因组中的基因表达了α-amanitin和phallotoxin，这是一种由鹅膏菌引起的致命性蘑菇中毒的循环毒素。在搜索后发现与编码已知NRPS的DNA不匹配，作者搜索了编码天冬酰胺和鬼笔毒素的氨基酸的循环排列。确实，蘑菇基因组包含一个金黄色素素基因AMA1和两个拷贝的鬼笔环肽基因PHA1。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2007年第48期|p.18876|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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Genes found for deadly mushroom toxins

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