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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
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Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury

机译：膳食亚硝酸盐补充剂可预防心肌缺血-再灌注损伤

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摘要

Nitrite has emerged as an endogenous signaling molecule with potential therapeutic implications for cardiovascular disease. Steady-state levels of nitrite are derived in part from dietary sources; therefore, we investigated the effects of dietary nitrite and nitrate supplementation and deficiency on NO homeostasis and on the severity of myocardial ischemia-reperfusion (MI/R) injury. Mice fed a standard diet with supplementation of nitrite (50 mg/liter) in their drinking water for 7 days exhibited significantly higher plasma levels of nitrite, exhibited significantly higher myocardial levels of nitrite, nitroso, and nitrosyl-heme, and displayed a 48% reduction in infarct size (Inf) after MI/R. Supplemental nitrate (1 g/liter) in the drinking water for 7 days also increased blood and tissue NO products and significantly reduced Inf. A time course of ischemia-reperfusion revealed that nitrite was consumed during the ischemic phase, with an increase in nitrosoitrosyl products in the heart. Mice fed a diet deficient in nitrite and nitrate for 7 days exhibited significantly diminished plasma and heart levels of nitrite and NO metabolites and a 59% increase in Inf after MI/R. Supplementation of nitrite in the drinking water for 7 days reversed the effects of nitrite deficiency. These data demonstrate the significant influence of dietary nitrite and nitrate intake on the maintenance of steady-state tissue nitriteitroso levels and illustrate the consequences of nitrite deficiency on the patho-physiology of MI/R injury. Therefore, nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a treatment modality for cardiovascular disease.
机译：亚硝酸盐已成为一种内源性信号分子，对心血管疾病具有潜在的治疗意义。亚硝酸盐的稳态水平部分来自饮食来源。因此，我们研究了饮食中亚硝酸盐和硝酸盐的补充和缺乏对NO稳态和心肌缺血再灌注（MI / R）损伤严重程度的影响。喂食标准饮食并在饮用水中补充亚硝酸盐（50 mg /升）的小鼠持续7天，其血浆亚硝酸盐水平明显升高，心肌中的亚硝酸盐，亚硝基和亚硝酰血红素水平明显升高，并且显示48％ MI / R后减少梗死面积（Inf）。在饮用水中补充硝酸盐（1克/升）7天，还会增加血液和组织中的一氧化氮产物，并显着降低Inf。缺血-再灌注的时间过程显示，在缺血阶段消耗了亚硝酸盐，心脏中的亚硝基/亚硝酰基产物增加。饲喂7天缺乏亚硝酸盐和硝酸盐饮食的小鼠的血浆和心脏中的亚硝酸盐和NO代谢物水平显着降低，MI / R后Inf升高59％。在饮用水中补充亚硝酸盐7天可以逆转亚硝酸盐缺乏症的影响。这些数据证明了饮食中亚硝酸盐和硝酸盐摄入量对维持稳态组织亚硝酸盐/亚硝基水平的重要影响，并说明了亚硝酸盐缺乏对MI / R损伤的病理生理的影响。因此，亚硝酸盐和硝酸盐可作为最佳心血管健康的必需营养素，并可为心血管疾病提供治疗方法。

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