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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Evolutionary plasticity of developmental gene regulatory network architecture
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Evolutionary plasticity of developmental gene regulatory network architecture

机译：发育基因调控网络架构的进化可塑性

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摘要

Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for embryo-genesis in these animals, we discovered an almost perfectly conserved five-gene network subcircuit required for endoderm specification. We show here that the GRN structure upstream and downstream of the conserved network kernel has, by contrast, diverged extensively. Mesoderm specification is accomplished quite differently; the Delta-Notch signaling system is used in radically distinct ways; and various regulatory genes have been coopted to different functions. The conservation of the conserved kernel is thus the more remarkable. The results indicate types of network linkage subject to evolutionary change. An emergent theme is that subcircuit design may be preserved even while the identity of genes performing given roles changes because of alteration in their cis-regulatory control systems.
机译：海星和海胆起源于大约半个世纪前的寒武纪末期的祖先。在体现这些动物胚胎发生的基因组程序的基因调控网络（GRN）的先前比较研究中，我们发现了内胚层规格所需的几乎完美保守的五基因网络子电路。相比之下，我们在这里表明，保守网络内核的上游和下游的GRN结构差异很大。中胚层规范的完成方式完全不同。 Delta-Notch信号系统以截然不同的方式使用；并且各种调节基因已被选为具有不同功能。因此，保守核的保守性更加显着。结果表明网络链接的类型可能会发生变化。一个新兴的主题是，即使执行特定角色的基因的身份由于其顺式调控系统的变化而发生变化，也可以保留子电路设计。

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