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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >NIX is required for programmed mitochondrial clearance during reticulocyte maturation
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NIX is required for programmed mitochondrial clearance during reticulocyte maturation

机译：网织红细胞成熟过程中线粒体清除需要NIX

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摘要

The regulated clearance of mitochondria is a well recognized but poorly understood aspect of cellular homeostasis, and defects in this process have been linked to aging, degenerative diseases, and cancer. Mitochondria are recycled through an autophagy-related process, and reticulocytes, which completely eliminate their mitochondria during maturation, provide a physiological model to study this phenomenon. Here, we show that mitochondrial clearance in reticulocytes requires the BCL2-related protein NIX (BNIP3L). Mitochondrial clearance does not require BAX, BAK, BCL-X_L, BIM, or PUMA, indicating that NIX does not function through established proapoptotic pathways. Similarly, NIX is not required for the induction of autoph-agy during terminal erythroid differentiation. NIX is required for the selective elimination of mitochondria, however, because mitochondrial clearance, in the absence of NIX, is arrested at the stage of mitochondrial incorporation into autophagosomes and autophago-some maturation. These results yield insight into the mechanism of mitochondrial clearance in higher eukaryotes. Furthermore, they show a BAX- and BAK-independent role for a BCL2-related protein in development.
机译：线粒体的调节清除是公认的细胞稳态方面，但该过程的缺陷与衰老，退行性疾病和癌症有关。线粒体通过自噬相关过程进行回收，网织红细胞在成熟过程中完全消除其线粒体，为研究这种现象提供了一种生理模型。在这里，我们显示网状细胞中的线粒体清除需要BCL2相关蛋白NIX（BNIP3L）。线粒体清除不需要BAX，BAK，BCL-X_L，BIM或PUMA，这表明NIX不能通过既定的促凋亡途径起作用。同样，在终末红系分化过程中自噬的诱导也不需要NIX。 NIX是选择性消除线粒体所必需的，但是，因为在没有NIX的情况下，线粒体清除在线粒体掺入自噬体和自噬体成熟阶段被阻止。这些结果使人们深入了解了高等真核生物中线粒体清除的机理。此外，它们在发育中对BCL2相关蛋白显示出BAX和BAK独立的作用。

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